Isco's first goal was a superb solo effort in the 17th to cancel out Duje Cop's opener for Sporting.
Zidane took no risks ahead of the return leg in Madrid and the upcoming Clasico, with Wales forward Gareth Bale rested as a precaution against a calf problem as he rotated the team from the midweek Champions League win at Bayern Munich.
"I'm anxious about it because I don't like to see players out injured and all the more so during the run-in", Zidane said.
Tottenham fans on Twitter have urged Mauricio Pochettino to go out and sign Real Madrid attacker Isco after his stunning Saturday display.
Possibly still scarred from their Champions League final defeat to bitter rivals Real Madrid in a shootout last season, Atletico Madrid are on a historic run of fluffing their lines from the spot.
Spain worldwide Isco offered a sublime demonstration of his value to Real Madrid with two excellent goals in the 3-2 win at Sporting.
Barcelona's center-back, Samuel Umtiti, scored a goal in the 42nd minute, and two minutes later Barcelona's Paco Alcacer scored his team's third victory goal.
Fresh off of making history yet again, Cristiano Ronaldo and Real Madrid look to continue their success when they face Sporting de Gijon on April 15. They had two chances and two goals.
Real Madrid have scored 18 goals after the 80th minute in #LaLiga this season; more than any other club.
Sporting restored their lead five minutes into the second half as Vesga headed home from close range, after being teed up by Babin.
And, despite 10 goals in all competitions this season, he remains a fringe player with coach Zinedine Zidane preferring a midfield three of Casemiro, Luka Modric and Toni Kroos.
"We know that it's a very important game and we're going to have to produce a great performance if we're to put any points on the board".
But not for Isco, who gave his coach good reason to play him more in the high-profile matches.
After the match Isco once again told the press that he's happy in Madrid and he wants to stay at the club.
The visit to Gijon may feel like an easy trip and a secondary event with Bayern and Barcelona on the horizon, but Real Madrid will find a fighting Sporting ready to pounce if they show any weaknesses.
Yannick Carrasco and Thomas Partey both saw penalties saved in the dying embers of Saturday's routine 3-0 win over Osasuna.
"It will be very hard, but I believe in the team and I am confident it will not be my last game in Europe".
"It is a relief to be able to take the three points, that is was what we wanted".